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Ally Olotu

Ally Olotu-Clinical.jpg
Email: 
aolotuatkilifi [dot] kemri-wellcome [dot] org
Group: 
Clinical Group

Research

Ally Olotu is a research clinician working with Clinical Trial Facility.He has been the co-principal investigator in the RTS,S phase IIb trial as well as sub-investigator in phase III trial. Ally graduated with Doctor of Medicine degree from University of Dar es salaam, Tanzania. He worked with Aga Khan Hospital, Dar es salaam for one year before joining the program in 2005. In 2006/2007 Ally won a WHO/TDR Career Development fellowship award and did his post-graduate training in the field of Research and Development in Malaria vaccine at TDR, Switzerland and GSKBiologicals, Belgium. He is currently registered for a Doctor of Philosophy (Dphil) in Clinical Epidemiology at University of Oxford since 2010. Ally is investigating the long term efficacy of a candidate malaria vaccine (RTS,S) in young children living in malaria endemic country. He is also assessing the vaccine induced correlates of protection in immunized children. He is being supervised by Dr Philip Bejon, Prof. Kevin Marsh and Gregory Fegan.

 

 

Collaborations

Dr Philip Bejon
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford,
United Kingdom
Malaria Vaccine Initiative (MVI) at PATH
GSK Biologicals

Publications

Selected Publications: 

1. Olotu A, Lusingu J, Leach A, Lievens M, Vekemans J, Msham S, Lang T, Gould J,Dubois MC, Jongert E, Vansadia P, Carter T, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Lapierre D, Ballou WR, Cohen J, Lemnge MM, Peshu N, Marsh K, Riley EM, von Seidlein L, Bejon P. Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial. Lancet Infect Dis. 2011 Feb;11(2):102-9. Epub 2011 Jan 13. Erratum in: Lancet Infect Dis. 2011 Mar;11(3):159. PubMed PMID: 21237715.

2. Olotu A, Fegan G, Williams TN, Sasi P, Ogada E, Bauni E, Wambua J, Marsh K,Borrmann S, Bejon P. Defining clinical malaria: the specificity and incidence of  endpoints from active and passive surveillance of children in rural Kenya. PLoS One. 2010 Dec 16;5(12):e15569. Erratum in: PLoS One. 2011;6(2). doi: 10.1371/annotation/fd5fdb2c-6cdd-429c-ae5c-24334795fe06. PubMed PMID: 21179571; PubMed Central PMCID: PMC3002959.

3. Olotu AI, Fegan G, Bejon P.Further analysis of correlates of protection from a phase 2a trial of the falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults. J Infect Dis. 2010 Mar 15;201(6):970-1. PubMed PMID: 20170369.

4. Bejon P, Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J, Mshamu S, Lang T, Gould J, Dubois MC, Demoitié MA, Stallaert JF, Vansadia P, Carter T, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Ballou WR, Cohen J, Riley EM, Lemnge MM, Marsh K, von Seidlein L. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N Engl J Med. 2008 Dec 11;359(24):2521-32. Epub 2008 Dec 8. PubMed PMID: 19064627; PubMed Central PMCID: PMC2655100.

5. Lusingu J, Olotu A, Leach A, Lievens M, Vekemans J, Olivier A, Benns S, Olomi R, Msham S, Lang T, Gould J, Hallez K, Guerra Y, Njuguna P, Awuondo KO, Malabeja A, Abdul O, Gesase S, Dekker D, Malle L, Ismael S, Mturi N, Drakeley CJ, Savarese B, Villafana T, Ballou WR, Cohen J, Riley EM, Lemnge MM, Marsh K, Bejon P, von Seidlein L.Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children. PLoS One. 2010 Nov 29;5(11):e14090. Erratum in: PLoS One. 2010;5(12) doi: 10.1371/annotation/0543a689-83a6-4528-92a1-a0f978b47fcb. PLoS One. 2010; 5(12)doi: 10.1371/annotation/3b62fdef-4cdd-40cc-b69d-69afd2000c4f. PubMed PMID:21124768; PubMed Central PMCID: PMC2993932.

6. Bejon P, Cook J, Bergmann-Leitner E, Olotu A, Lusingu J, Mwacharo J, Vekemans J, Njuguna P, Leach A, Lievens M, Dutta S, von Seidlein L, Savarese B, Villafana T, Lemnge MM, Cohen J, Marsh K, Corran PH, Angov E, Riley EM, Drakeley CJ. Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children. J Infect Dis. 2011 Jul;204(1):9-18. PubMed PMID: 21628653; PubMed Central PMCID: PMC3105039.

7. Kariuki SM, Ikumi M, Ojal J, Sadarangani M, Idro R, Olotu A, Bejon P, Berkley JA, Marsh K, Newton CR. Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast. Brain. 2011 May;134(Pt 5):1519-28. Epub 2011 Apr 10. PubMed PMID: 21482551; PubMed Central PMCID: PMC3097888.

8. Bejon P, Williams TN, Liljander A, Noor AM, Wambua J, Ogada E, Olotu A, Osier FH, Hay SI, Färnert A, Marsh K. Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya. PLoS Med. 2010 Jul 6;7(7):e1000304. Erratum in: PLoS Med. 2011 Feb;8(2). doi: 10.1371/annotation/592709c8-8f86-4f40-968b-1e7e051ab491. PubMed PMID: 20625549; PubMed Central PMCID: PMC2897769.

9. Bejon P, Turner L, Lavstsen T, Cham G, Olotu A, Drakeley CJ, Lievens M, Vekemans J, Savarese B, Lusingu J, von Seidlein L, Bull PC, Marsh K, Theander TG. Serological Evidence of Discrete Spatial Clusters of Plasmodium falciparum Parasites. PLoS One. 2011;6(6):e21711. Epub 2011 Jun 29. PubMed PMID: 21747921;PubMed Central PMCID: PMC3126844.

10. Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, Guindo AB, Traore K,Sissoko M, Diallo DA, Diarra I, Kouriba B, Daou M, Dolo A, Baby M, Sissoko MS, Sagara I, Niangaly A, Traore I, Olotu A, Godeaux O, Leach A, Dubois MC, Ballou WR, Cohen J, Thompson D, Dube T, Soisson L, Diggs CL, Takala SL, Lyke KE, House B, Lanar DE, Dutta S, Heppner DG, Plowe CV.Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial. PLoS One. 2010 Feb 4;5(2):e9041. PubMed PMID: 20140214; PubMed Central PMCID: PMC2816207.

11.Bejon P, Abdulla S, Lusingu J, Olotu A, Leach A, Lievens M, Tanner M, von Seidlein L. Response to "Poor control vaccines in two randomised trials of malaria vaccine?". Vaccine. 2009 Jul 30;27(35):4745-6. Epub 2009 May 30. PubMed PMID: 19486956; PubMed Central PMCID: PMC2713779.

12. Olotu A, Ndiritu M, Ismael M, Mohammed S, Mithwani S, Maitland K, Newton CR.Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children. Resuscitation. 2009 Jan;80(1):69-72. Epub 2008 Nov 14. PubMed PMID: 19013705; PubMed Central PMCID: PMC2706393.

13. Olotu AI, Mithwani S, Newton CR. Haemolytic uraemic syndrome in children admitted to a rural district hospital in Kenya. Trop Doct. 2008 Jul;38(3):165-7.PubMed PMID: 18628547

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