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Brett Lowe
gmail [dot] com Research
Brett joined the Kilifi KEMRI-Wellcome programme in April 1992 and has been instrumental in the development of the programme's laboratory based research to its current status.
Currently, Brett is based at the Muhimbili Wellcome Trust Programme in Dar-es-Salaam, Tanzania where he is working to develop a high quality laboratory infrastructure to underpin the current and proposed research agenda there.
Major milestones with the programme:
Designing and over-seeing the construction of the Centre's new laboratories and office facilities - completed in 2005.
Establishing international recognition of the laboratories' quality management systems with GCLP Accreditation - awarded in 2007.
Qualifications:
Master of Philosophy - Malaria Immunology - Department of Medicine, University of Liverpool, UK
Higher National Diploma - Clinical Chemistry - University of Manchester, UK
Previous appointments:
8 years - NHS Diagnostic Laboratory Services in the North of England, UK.
4 years - WHO Technical Adviser to the National Public Health Laboratories in Kathmandu, Nepal.
6 years - Tutor in the Department of Medical Parasitology, Liverpool School of Hygiene and Tropical Medicine, UK.
Publications
Färnert A, Williams TN, Mwangi TW, Ehlin A, Fegan G, Macharia A, Lowe BS, Montgomery SM, Marsh K. Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection. Journal of Infectious Diseases. October 2009.
Berkley JA, Bejon P, Mwangi T, Gwer S, Maitland K, Williams TN, Mohammed S, Osier F, Kinyanjui S, Fegan G, Lowe BS, English M, Peshu N, Marsh K, Newton CR. HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria. Clinical Infectious Diseases. August 2009.
Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS, Peshu N, Newton CR, Marsh K. Defining childhood severe falciparum malaria for intervention studies. PLoS Medicine. August 2007.
Bejon P, Peshu N, Gilbert SC, Lowe BS, Molyneux CS, Forsdyke J, Lang T, Hill AV, Marsh K. Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya. Clinical Infectious Diseases. April 2006.
Polley SD, Conway DJ, Cavanagh DR, McBride JS, Lowe BS, Williams TN, Mwangi TW, Marsh K. High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya. Vaccine. May 2006.
Scott JA, Mwarumba S, Ngetsa C, Njenga S, Lowe BS, Slack MP, Berkley JA, Mwangi I, Maitland K, English M, Marsh K. Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002. Antimicrobial Agents and Chemotherapy. July 2005.
Bejon P, Mwangi I, Ngetsa C, Mwarumba S, Berkley JA, Lowe BS, Maitland K, Marsh K, English M, Scott JA. Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya. The Journal of Antimicrobial Chemotherapy. July 2005.
Dorfman JR, Bejon P, Ndungu FM, Langhorne J, Kortok MM, Lowe BS, Mwangi TW, Williams TN, Marsh K. B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area. Journal of Infectious Diseases. May 2005.
Berkley JA, Maitland K, Mwangi I, Ngetsa C, Mwarumba S, Lowe BS, Newton CR, Marsh K, Scott JA, English M. Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. British Medical Journal. April 2005.
Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA, Maitland K, English M, Marsh K, Scott JA. Bacteremia among children admitted to a rural hospital in Kenya. New England Journal of Medicine. January 2005.