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Charles Newton
kilifi [dot] kemri-wellcome [dot] org Research
Charles Newton was born in Kenya, qualified in Cape Town, South Africa, with postgraduate training in Paediatrics in Manchester and London, United Kingdom. As a lecturer at University of Oxford, he came out to Kilifi in 1989, to help set up the Kilifi unit to study severe malaria in African children. Thereafter he spent 2 years as a Post-doctoral fellow at Johns Hopkins, USA; studying mechanisms of brain damage in central nervous system infections. He completed his neurology training at Great Ormond Street Hospital, UK. In 1998 he was awarded a Wellcome Trust Senior Clinical Fellowship to return to Kilifi, to study CNS infections in children. He became Head of Clinical Research in Kilifi, and has published on a wide variety of subjects concerning sick children in tropical countries, with over 200 publications. He continues to conduct research on CNS infections in children, particularly malaria, meningitis and neonatal sepsis; neonatal tetanus and jaundice; and sick children admitted to district hospitals in Africa. At present he is conducting epidemiological studies of epilepsy in five countries in Africa and is leading the Muhimbili-Wellcome Trust collaborative programme in Dar-es-Salaam, where the research is focused on sickle cell disease and epilepsy.
Publications
Wildig JW, Cossart Y, Peshu N, Gicheru N, Tuju J, Williams TN, Newton CR. Parvovirus B19 infection and severe anaemia in Kenyan children: a retrospective case control study. BMC Infect Dis. 2010 Apr 3; 10 (1) :88. PubMed PMID: 20361872.
Kihara M, Hogan AM, Newton CR, Garrashi HH, Neville BR, de Haan M. Auditory and visual novelty processing in normally-developing Kenyan children. Clin Neurophysiol. 2010 Apr; 121 (4) :564-76. PubMed PMID: 20080442; PubMed Central PMCID: PMC2842935.
Mwaniki M, Mathenge A, Gwer S, Mturi N, Bauni E, Newton CR, Berkley J, Idro R. Neonatal seizures in a rural Kenyan District Hospital: aetiology, incidence and outcome of hospitalization. BMC Med. 2010 Mar 17; 8:16. PubMed PMID: 20236524; PubMed Central PMCID: PMC2846860.
Idro R, Newton C, Kiguli S, Kakooza-Mwesige A. Child Neurology Practice and Neurological Disorders in East Africa. J Child Neurol. 2010 Feb 5; PubMed PMID: 20139410.
Makani J, Komba AN, Cox SE, Oruo J, Mwamtemi K, Kitundu J, Magesa P, Rwezaula S, Meda E, Mgaya J, Pallangyo K, Okiro E, Muturi D, Newton CR, Fegan G, Marsh K, Williams TN. Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization. Blood. 2010 Jan 14; 115 (2) :215-20. PubMed PMID: 19901265; PubMed Central PMCID: PMC2843825.
Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: A meta-analytic approach. Epilepsia. 2010 Jan 7; PubMed PMID: 20067507.
Gona JK, Xiong T, Muhit MA, Newton CR, Hartley S. Identification of people with disabilities using participatory rural appraisal and key informants: a pragmatic approach with action potential promoting validity and low cost. Disabil Rehabil. 2010; 32 (1) :79-85. PubMed PMID: 19925280.
Warimwe GM, Keane TM, Fegan G, Musyoki JN, Newton CR, Pain A, Berriman M, Marsh K, Bull PC. Plasmodium falciparum var gene expression is modified by host immunity. Proc Natl Acad Sci U S A. 2009 Dec 22; 106 (51) :21801-6. PubMed PMID: 20018734; PubMed Central PMCID: PMC2792160.
Helbok R, Kendjo E, Issifou S, Lackner P, Newton CR, Kombila M, Agbenyega T, Bojang K, Dietz K, Schmutzhard E, Kremsner PG. The Lambaréné Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children. J Infect Dis. 2009 Dec 15; 200 (12) :1834-41. PubMed PMID: 19911989.
Abubakar A, Holding P, Newton CR, van Baar A, van de Vijver FJ. The role of weight for age and disease stage in poor psychomotor outcome of HIV-infected children in Kilifi, Kenya. Dev Med Child Neurol. 2009 Dec; 51 (12) :968-73. PubMed PMID: 19486107.