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D James Nokes

Prof James Nokes.jpg
Email: 
jnokesatkilifi [dot] kemri-wellcome [dot] org

Research

Research area
Epidemiology and control of viral pathogens

Research overview
Our research centres on the epidemiology of medically important viral pathogens in the developing country setting, in particular respiratory syncytial virus (RSV) and rotavirus. The emphasis is on improved understanding of the determinants of infection dynamics, in relation to host behaviour, demography and immunity, and of parasite transmissibility and antigenic diversity, and to provide a framework for the rational design of control programmes. Projects combine community-based studies in households and schools, immunology and molecular characterisation, and mathematical and statistical modelling. The research is multidisciplinary and collaborative, with applications to public health policy.

 

Collaborations

Graham Medley
University of Warwick
United Kingdom
Pat Cane
Health Protection Agency
United Kingdom
Lisa White
Wellcome Trust
Thailand
Peter Openshaw
National Heart and Lung Institute, Imperial College
United Kingdom
Marietjie Venter
Department of Medical Virology, University of Pretoria
South Africa
David Brown
Enteric, Respiratory & Neurological Virus Research Laboratory, Health Protection Agency
United Kingdom
Nicci Page
Viral Gastroenteritis Unit, National Institute for Communicable Diseases, Sandringham
South Africa
Ina Peenze & Duncan Steele
MRC/Diarrhoeal Pathogens Research Unit (DPRU), University of Limpopo
South Africa
Joel Mossong
Department of Microbiology, Laboratoire National de Santé
Luxembourg

Publications

Selected Publications: 
  1. Nokes DJ, Peenze I, Netshifhefhe L, Abwao J, De Beer MC, Seheri M, Williams TN, Page N, Steele D. Rotavirus genetic diversity, disease association and temporal change in hospitalized rural Kenyan children. J Infect Dis 2010;202 Suppl:S180-6
  1. Berkley JA, Munywoki P, Ngama M, Kazungu S, Abwao J, Bett A, Lassauniere R, Kresfelder T, Cane PA, Venter M, Scott JA, Nokes DJ. Viral etiology of severe pneumonia among Kenyan infants and children. JAMA 2010;303(20):2051-7.
  1. Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, O'Brien KL, Roca A, Wright PF, Bruce N, Chandran A, Theodoratou E, Sutanto A, Sedyaningsih ER, Ngama M, Munywoki PK, Kartasasmita C, Simoes EA, Rudan I, Weber MW, Campbell H. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010;375(9725):1545-55
  1. Medley GF, Nokes DJ. Does viral diversity matter? Epidemiology Perspectives. Science 2009; 325:274-5.
  1. White LJ, Buttery J, Cooper B, Nokes DJ and Medley GF. Rotavirus within day care centres in Oxfordshire, UK: characterization of partial immunity. J R Soc Interface 2008;5:1481-90
  1. Nokes DJ, Abwao J, Pamba A, Peenze I,  Dewar J,  Maghenda JK, Gatakaa H, Bauni E, Scott JA, Maitland K, Williams TN. Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya. PLoS Med 2008;5:e153
  1. Nokes, D. J., Okiro, E. A., Ngama, M., Ochola, R., White, L. J., Scott, P. D., English, M., Cane, P. A., and Medley, G. F. Respiratory syncytial virus infection and disease in infants and young children studied from birth in Kilifi District, Kenya. Clinical Infectious Diseases, 2008, 46:50-7.
  1. Scott, P. D., Ochola, R., Sande, C., Ngama, M., Okiro, E. A., Medley, G. F., Nokes, D., and Cane, P. A. Comparison of strain specific antibody responses during primary and secondary infections with respiratory syncytial virus. Journal of Medical Virology, 2007, 79: 1943-50.
  1. White, L.J., Mandl, J.N., Gomes, M.G.M., Bodley-Tickell, A.T., Cane, P.A., Perez-Brena, P., Aguilar, J.C., Siqueira, M.M., Portes, S.A., Straliotto, S.M., Waris, M., Nokes, D.J.,& Medley, G.F. Understanding the transmission dynamics of respiratory syncytial virus using multiple time series and nested models. Mathematical  Biosciences  2007, 209, 222-39.
  1. Scott, P. D., Ochola, R., Ngama, M., Okiro, E. A., Nokes, D. J., Medley, G. F. & Cane, P. A. Molecular analysis of respiratory syncytial virus reinfections in infants from coastal Kenya. Journal of Infectious Diseases 2006, 193: 59-67.
  1. White, L. J., Waris, M., Cane, P. A., Nokes, D. J. & Medley, G. F.  The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection. Epidemiology and Infection  2005, 133: 279-89.
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