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Jay Berkley has a broad research interest in childhood infection in sub-Saharan Africa. He is a Wellcome Trust Intermediate Clinical Research Fellow and a Consultant in Paediatric Clinical Immunology & Infectious Diseases. The group focuses on the relationships between malnutrition and infection in children, including clinical epidemiology and understanding basic mechanisms, leading to novel interventions both sides of the cycle of malnutrition, impaired immunity and infection.
Jay joined the KEMRI/Wellcome Trust Collaborative Research Programme in Kilifi, Kenya in 1997. After working for a year as a clinician, he undertook a Wellcome Trust Research Training Fellowship on invasive bacterial infections, and their relationships with malaria, HIV and malnutrition. After completing specialist training in paediatrics and sub-specialist training in immunology and infectious diseases in the UK, Jay returned to Kilifi. He undertook a study of the viral aetiology of severe pneumonia (Wellcome Trust Project Grant) and then started the current Intermediate Clinical Research Fellowship on nutrition and infection.
Berkley JA, Bejon P, Mwangi T, Gwer S, Maitland K, Williams TN, Mohammed S, Osier F, Kinyanjui S, Fegan G, Lowe BS, English M, Peshu N, Marsh K, Newton CRJC. HIV, malnutrition and invasive bacterial infections among children with severe malaria. In press: Clinical Infectious Diseases.
Bejon P, Mohammed S, Mwangi I, Atkinson S, Osier F, Peshu N, Newton CR, Maitland K, Berkley JA. The fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya. Am J Clin Nutr 2008; 88(6):1626-31.
Heikens GT,Bunn J,Amadi B, Manary M, Chhagan M, Berkley JA, Rollins N, Kelly P, Adamczick C, Maitland K, Tomkins A, for the Blantyre Working Group. Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. Lancet 2008; 371: 1305-07.
Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, Williams T, Scott JA, English M, Lowe BS, Peshu N, Newton CR, Marsh K. Defining childhood severe falciparum malaria for intervention studies. PLoS Med. 2007 Aug;4(8):e251.
Maitland K, Berkley JA, Shebbe M, Peshu N, English M, Newton CR. Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol? PLoS Med. 2006 Dec;3(12):e500.
Berkley JA, Mwangi I, Griffiths K, Ahmed I, Mithwani S, English M, Newton CRJC, Maitland K. Assessment of Severe Malnutrition Among Hospitalized Children in Rural Kenya: Comparison of Weight for Height and Mid-Upper Arm Circumference. JAMA 2005;294:591-7.
Berkley JA, Maitland K, Mwangi I, Ngetsa C, Mwarumba S, Lowe BS, Newton CR, Marsh K, Scott JA, English M. Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study. BMJ. 2005 Apr 30;330:995.
Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA, Maitland K, English M, Marsh K, Scott JA. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005 Jan 6;352(1):39-47.
Berkley JA, Versteeg AC, Mwangi I, Lowe BS, Newton CR. Indicators of acute bacterial meningitis in children at a rural Kenyan district hospital. Pediatrics. 2004 ;14(6):e713-9.
Berkley JA, Ross A, Mwangi I, Osier FH, Mohammed M, Shebbe M, Lowe BS, Marsh K, Newton CR. Prognostic indicators of early and late death in children admitted to district hospital in Kenya: a cohort study. BMJ. 2003;326(7385):361.
Berkley JA, Mwangi I, Ngetsa CJ, Mwarumba S, Lowe BS, Marsh K, Newton CR. Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa. Lancet. 2001;357(9270):1753-7.
Berkley J, Mwarumba S, Bramham K, Lowe B, Marsh K. Bacteraemia complicating severe malaria in children. Trans R Soc Trop Med Hyg. 1999;93(3):283-6.
Berkley JA, Mwangi I, Mellington F, Mwarumba S, Marsh K. Cerebral malaria versus bacterial meningitis in children with impaired consciousness. QJM. 1999;92(3):151-7.