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Julie Makani
yahoo [dot] com Research
Principle Investigator of the Sickle Cell Research Project
Senior lecturer and specialist physician in the Department of Haematology and Blood Transfusion at Muhimbili University of Health and Allied Sciences (MUHAS) http://www.muhas.ac.tz
Clinical Research fellow in the Nuffield department of clinical medicine, Oxford University http://www.ndm.ox.ac.uk/researcher/julie-makani
Member of the Royal College of Physicians of United Kingdom
Technical advisor to the Global SCD Research Network - co-chairing the working group responsible for Hydroxyurea Therapy in Africa and other Developing Regions
In 2001, she started collaborating with the KEMRI-Wellcome programme when conducting clinical studies on adult malaria in Dar-es-Salaam. Following this study, she identified haematology as an interesting clinical area and sickle cell disease (SCD) as a major but neglected problem. Due to its molecular basis, SCD presents great opportunities for integrating clinical, epidemiological, patho-physiological and genetic research. SCD confers protection against malaria infection and Muhimbili is a collaborative site for Malaria Genomic Epidemiology Network (MalariaGEN) Grand Challenges Programme. http://www.malariagen.net/
She received a Training fellowship from the Wellcome Trust to establish a systematic framework for comprehensive research and care, with one of the largest single-centre cohorts of SCD patients in the world. SCD presents great opportunities for integrating clinical, epidemiological, patho-physiological and genetic research and to test the paradigm of translation of research in genomic medicine into improvement in health.
Collaborations
Publications
Makani J, Komba AN, Cox SE, Oruo J, Mwamtemi K, Kitundu J, Magesa P, Rwezaula S, Meda E, Mgaya J, Pallangyo K, Okiro E, Muturi D, Newton CR, Fegan G, Marsh K, Williams TN. Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization. Blood. 2010 Jan
Williams TN, Uyoga S, Macharia A, Ndila C, McAuley CF, Opi DH, Mwarumba S, Makani J, Komba A, Ndiritu MN, Sharif SK, Marsh K, Berkley JA, Scott JA. Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study. Lancet. 2009 Oct
Sadarangani M, Makani J, Komba AN, Ajala-Agbo T, Newton CR, Marsh K, Williams TN. An observational study of children with sickle cell disease in Kilifi, Kenya. Br J Haematol. 2009 Sep
Komba AN, Makani J, Sadarangani M, Ajala-Agbo T, Berkley JA, Newton CR, Marsh K, Williams TN. Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya. Clin Infect Dis. 2009 Jul
Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, Sanjoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP; Wellcome Trust Case Control Consortium; Malaria Genomic Epidemiology Network. Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009 May
Makani J, Kirkham FJ, Komba A, Ajala-Agbo T, Otieno G, Fegan G, Williams TN, Marsh K, Newton CR. Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness. Br J Haematol. 2009 May
Makani J. A global network for investigating the genomic epidemiology of malaria. Malaria Genomic Epidemiology Network. Nature. 2008 Dec
Chokshi DA, Thera MA, Parker M, Diakite M, Makani J, Kwiatkowski DP, Doumbo OK. Valid consent for genomic epidemiology in developing countries. PLoS Med. 2007 Apr
Makani J, Williams TN, Marsh K. Sickle cell disease in Africa: burden and research priorities. Ann Trop Med Parasitol. 2007 Jan
Herbert G, Ndiritu M, Idro R, Makani JB, Kitundu J. Analysis of the indications for routine lumbar puncture and results of cerebrospinal fluid examination in children admitted to the paediatric wards of two hospitals in East Africa. Tanzan Health Res Bull. 2006 Jan