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My group aims to identify new targets of malaria intervention by identifying and characterizing subsets of PfEMP1 that are associated with infections of children with low natural immunity at different points in time.
See projects for more information.
G. M. Warimwe, G. Fegan, J. N. Musyoki, C. R. Newton, M. Opiyo, G. Githinji, C. Andisi, F. Menza, B. Kitsao, K. Marsh, P. C. Bull, Prognostic Indicators of Life-Threatening Malaria Are Associated with Distinct Parasite Variant Antigen Profiles. Sci. Transl. Med. 4, 129ra45 (2012). Abstract Reprint Full Text
Warimwe GM, Kean, TM, Fegan G, Musyokia JN, Newton CRJC, Pain A, Berriman M, Marsh K, Bull PC. (2009) Plasmodium falciparum var gene expression is modified by host immunity Proc. Natl, Acad, Sci. USA (106) 21801-21806
Buckee CO, Bull PC, Gupta S. (2009) Inferring malaria parasite population structure from serological networks. Proc Biol Sci. (276) 477-85.
Bull PC, Buckee CO, Kyes S, Kortok MM, Thathy V, Guyah B, Stoute JA, Newbold CI, Marsh K. (2008) Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks. Mol Microbiol. (68) 1519-1534.
Bull PC, Berriman M, Kyes S, Quail MA, Hall N, Kortok MM, Marsh K, Newbold CI. (2005) Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria. PLoS Pathogens. (1), e26 202-213.
Bull PC, Pain A, Ndungu FM, Kinyanjui SM, Roberts DJ, Newbold CI, Marsh K. (2005) Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severity. J. Infect Dis. 2005 (192) 1119-26.
Recker, M., Nee, S. , Bull, P.C., Kinyanjui, Marsh, K., Newbold, C.I., and Gupta, S. (2004). Transient cross-reactive immune responses can maintain antigenic variation in malaria (2004) Nature (429) 555-8.