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Daily cotrimoxazole prophylaxis following nutritional rehabilitation among children

Full Title: 
A randomized trial of daily cotrimoxazole prophylaxis following nutritional rehabilitation among children with severe malnutrition.
Principal Investigator(s): 
Jay Berkley

This project aims to test the hypothesis that mortality among Kenyan children with severe malnutrition following initial stabilisation is due to ongoing vulnerability to infectious disease, and that cotrimoxazole prophylaxis will reduce mortality. The primary endpoint is death. Secondary endpoints include the effects on growth, hospital admission, markers of inflammation, immune activation and immune function. We are also examining antibiotic resistance and changes in microbiota with prophylaxis.