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Current and planned clinical trials

SHORT TITLEFULL TITLEPRINCIPLE INVESTIGATOR
RTSS MAL055A phase III, double blind (observer-blind), randomized controlled Multi-centre study to evaluate, in infants and children, the efficacy of the RTS,S/ASO1E candidate vaccine against malaria disease caused by P.falciparum infection,across diverse malaria transmission settings in Africa

Roma Chilengi

Patricia Njuguna


CTXRandomized, double-blind, placebo controlled trial of Cotrimoxazole prophylaxis among HIV-uninfected children with severe malnutrition Jay Barkley
Trap VacSafety and immunogenicity of heterologous prime-boost with the candidate malaria vaccines AdCh63 ME-TRAP and MVA ME-TRAP in healthy adults in a malaria endemic area Roma Chilengi
FerroquineA phase II , parallel group, double-blind, randomized study assessing the efficacy, safety and pharmacokinetics profiles of Ferroquine associated with Artesunate and a single-blind dose level of Ferroquine alone in a 3-day treatment of uncomplicated malaria due to Plasmodium falciparum in an immune symptomatic African adult and paediatric population

Roma Chilengi

NNJThe causes, interventions and neurodevelopmetal outcome of neonates admitted with severe hyperbilirubinemia to a kenyan rural hospital Michael Mwaniki
FOSCOMA randomized double blind placebo controlled trial of fosphenytoin for prevention of seizures in children with acute non-traumatic encephalopathies Charles Newton/ Samson Gwer
EndotoxEndotoxaemia in severe and complicated malnutrition
Kathryn Maitland
FEAST:

A randomised trial of fluid resuscitation strategies in African children with severe febrile illness and clinical evidence of impaired perfusion

Kathryn Maitland
PRISMReactogenicity and immunogenicity of 10-valent pneumococcal conjugate vaccine in children Laura Hammit
MAL059 An extended follow-up of a phase II b vaccine trial with RTS,S/ASOIE in Kilifi district, KenyaAlly Olotu
PrEP A pilot study of Pre-Exposure Prophylaxis (PrEP) to evaluate safety, acceptability, and adherence in at-risk populations in Kenya, Africa (IAVI E001)Eduard Sanders
ARIEL A Phase II, open-label trial to evaluate pharmocokinetics, safety, tolerability and antiviral activity of DRV in comination with low dose ritonavir (DRV/rtv) in treatment-experienced HIV-1 infected children from 3 years to < 6 years of ageRobrt Kimutai