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haemoglobinopathy

Identifying genetic factors determining foetal haemoglobin levels in Sickle Cell Disease

Principal Investigator(s): 
Julie Makani

Other investigators/ Supervisors:
Prof. SL Thein (Kings College, London)
Prof. S Menzel (Kings College, London)

Mapping inherited blood disorders in Kenya

Principal Investigator(s): 
Thomas N Williams

From the global MAP-IBD data archive, gaps in our knowledge of the distribution of malaria related IBDs have become apparent. The MPHEG's engagement in national sample surveys of infection in Kenya and regionally will open opportunities to increase the standardized description of the spatial distribution of human malaria protective gene frequencies (HbS, Glucose-6-phosphate dehydrogenase deficiency, thalassemias and Duffy coat negativity). This will enable us to better articulate HbS homozygote disease burdens, provide an informed public health decision framework for novel deployment of new pro-oxidant drugs that have haemolytic adverse effects in G6PD deficient populations, examine hypotheses of FY*O homozygote prevalence and the likelihood of P.

Thomas N Williams

thomas-williams-photo-thumb.jpg
Email: 
twilliamsatkilifi [dot] kemri-wellcome [dot] org
Group: 
Epidemiological and Demographic Surveillance System (EPI-DSS)