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epidemiology

Julie Makani

Julie Makani
Email: 
juliemakaniatyahoo [dot] com
Group: 
Sickle Cell Disease (Dar es Salaam)

Principle Investigator of the Sickle Cell Research Project

Francis Ndungu

francis-ndungu.jpg
Email: 
fndunguatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Immunity to malaria is slow to develop, is non-sterilising and wanes rapidly when immune adults migrate to non-endemic regions, suggesting that specific problems exist in the establishment and main

Prevalence, incidence and mortality of epilepsy in Sub-Saharan Africa

Principal Investigator(s): 
Anthony K. Ngugi

No description available.

Anthony K. Ngugi

anthony-ngugi.jpg
Email: 
angugiatkilifi [dot] kemri-wellcome [dot] org
Group: 
Clinical Group

Epilepsy is one of the commonest neurological disorders affecting more than 50 million people worldwide; out of whom 40 million live in resource poor countries (RPC) with10 million in Africa alone.

Epidemiology of HIV and acute HIV infections in vulnerable populations

Principal Investigator(s): 
Eduard Sanders

No description available.

Steffen Borrmann

Steffen-Borrmann.jpg
Email: 
steffen [dot] borrmannatgmail [dot] com
Group: 
Molecular Parasitology and Immunology

Research area: Epidemiology of drug-parasite and host-parasite interactions

Rotavirus

Principal Investigator(s): 
D James Nokes

Rotavirus is the major cause of paediatric severe diarrhoea worldwide. The virus is antigenically variable, with diversity arising from immune driven drift and reassortment of its segmented RNA genome during superinfections of human and animal strains. In Africa in particular the occurrence of unusual variant combinations of the immunodiminant G and P types is very high. Live attenuated vaccines, shown to be highly effective where they have been so far trialed, are increasingly being implemented within universal infant immunization schedules.

Repiratory Syncytial Virus (RSV)

Principal Investigator(s): 
D James Nokes

A main focus of our current research is the transmission dynamics of respiratory syncytial virus, the major viral cause of infant and childhood severe pneumonia worldwide. RSV, as it is known, exhibits considerable genetic diversity (Groups A and B and within each a set of variants) which is apparently under immune selection. Occurrence of the virus is structured at the population level exhibiting sequential dominance of these variants; presumably resulting from (localised) strain specific herd immunity that provides competitive fitness to the least prevalent strains.

Epidemiology of malaria transmission in neglected, semi-arid areas of Africa

Principal Investigator(s): 
Abdisalan Mohamed Noor

Unlike stable transmission settings in Africa the drivers of focal, heterogeneous infection and disease risks among the arid areas of Africa remain poorly defined. The populations in North West and North Eastern Kenya are poor, semi-nomadic groups with little acquired functional immunity to P. falciparum, marginalized by the 2001-09 national malaria strategy as they were assumed to be at no risk. Risks however, appear to be very focal concentrated in areas of seasonal water which also determines where people live. A more detailed empirical investigation of malaria risk, including susceptibility to P.