The research agenda of the programme is led by 31 principal investigators (researchers with their own funding), of which 23 are Wellcome funded and 14 hold Wellcome Fellowships. Research falls into five major disciplines: Clinical sciences, Epidemiology and Demography, Pathogen Biology, Public Health Policy and Health systems, and Social and Behavioural research. To take account of geographical distribution there are eight functional reporting groups or clusters. There is considerable interaction within and between divisions and functional reporting groups with a number of overarching programmatic activities involving many groups.