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pathogens

Francis Ndungu

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Email: 
fndunguatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Immunity to malaria is slow to develop, is non-sterilising and wanes rapidly when immune adults migrate to non-endemic regions, suggesting that specific problems exist in the establishment and main

Margaret Mackinnon

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Email: 
mmackinnonatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

What is it that causes pathogens to harm their host? In my lab, we study the evolutionary pressures, and the biology underlying them, that make pathogens virulent.

Rotavirus

Principal Investigator(s): 
D James Nokes

Rotavirus is the major cause of paediatric severe diarrhoea worldwide. The virus is antigenically variable, with diversity arising from immune driven drift and reassortment of its segmented RNA genome during superinfections of human and animal strains. In Africa in particular the occurrence of unusual variant combinations of the immunodiminant G and P types is very high. Live attenuated vaccines, shown to be highly effective where they have been so far trialed, are increasingly being implemented within universal infant immunization schedules.

Aetiology and disease burden of respiratory and enteric viral pathogens

Principal Investigator(s): 
D James Nokes

• Viral aetiology, epidemiology and disease burden of paediatric pneumonia hospitalisations in the coastal Kenyan setting.

• Disease burden and genetic diversity of rotavirus in hospitalized rural Kenyan children

• Investigating the aetiology and spatial-temporal risk factors of diarrhoeal pathogens using a broad spectrum real-time PCR detection assay

Evelyn Gitau

Email: 
egitauatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Modern molecular typing techniques now permit to identify rapidly var genes encoding dominant expressed PfEMP-1 variants in a given isolate and allow for the first time to define cellular immune re

Britta C Urban

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Email: 
burbanatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Britta Urban obtained a PhD at the Bernhard-Nocht Institute for Tropical Medicine in Hamburg, Germany in 1996, investigating complement resistance of Entamoeba histolytica.

Faith Osier

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Email: 
fosieratkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

People living in malaria-endemic areas become immune to death from severe malaria essentially by the age of five years, and develop immunity against mild clinical episodes at variable rates.

Pete Bull

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Email: 
pbullatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

My group aims to identify new targets of malaria intervention by identifying and characterizing subsets of PfEMP1 that are associated with infections of children with low natural immunity at diff

Kevin Marsh

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Email: 
kmarshatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Professor Kevin Marsh has a broad research interest in child health in the tropics, with a particular focus in the immune epidemiology of malaria.

(Lynette) Isabella Ochola

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Email: 
liocholaatkilifi [dot] kemri-wellcome [dot] org
Group: 
Molecular Parasitology and Immunology

Studies of natural selection on merozoite genes. Previous work on merozoite antigens, such as AMA1, MSP1 and EBA175 have shown evidence of these genes being under balancing selection.